Next Article in Journal
Coordination Polymers Based on Phthalic Acid and Aminopyrazine Ligands: On the Importance of N–H···π Interactions
Next Article in Special Issue
A Novel Application of Phosphorene as a Flame Retardant
Previous Article in Journal
Elucidation of Spatial Distribution of Hydrophobic Aromatic Compounds Encapsulated in Polymer Micelles by Anomalous Small-Angle X-ray Scattering
Previous Article in Special Issue
Sortase-Mediated Ligation of Purely Artificial Building Blocks
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(2), 181; https://doi.org/10.3390/polym10020181

Polycomplexes of Hyaluronic Acid and Borates in a Solid State and Solution: Synthesis, Characterization and Perspectives of Application in Boron Neutron Capture Therapy

1
R&D Center “Suisselle,” CEI3, rue Galilée 6, 1400 Yverdon-les-Bains, Switzerland
2
Institute of Synthetic Polymer Materials, Russian Academy of Sciences, Profsoyuznaya st. 70, 117393 Moscow, Russian
3
Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
4
Institute for Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334 Moscow, Russian
5
Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama 236-0004, Japan
*
Authors to whom correspondence should be addressed.
Received: 5 January 2018 / Revised: 3 February 2018 / Accepted: 10 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Polymer Hybrid Materials)
View Full-Text   |   Download PDF [2493 KB, uploaded 13 February 2018]   |  

Abstract

In this report, we propose a new polyborate fragment synthesis strategy along the whole chain of the polysaccharide hyaluronic acid (HA) to produce boron neutron capture therapy (BNCT) compounds. Under high pressure and deformatory solid-state conditions, polymolecular system formation takes place due to association of phase-specific transition components into a more or less distinct microscopic organization. Fourier transform infrared (FTIR) spectroscopy shows that HA and polyborates form a network of cyclic polychelate complexes. HA acts as a multidentate ligand using carboxylic and hydroxyl proton donor groups to link oxygen atoms in B–O–B bonds and borate-anions B–O(−): O–H···O, O–H···(−)O. With free electron pairs in heteroatoms –O(:)···B, –N(:)···B, HA can act simultaneously as an electron donor. Nuclear magnetic resonance (NMR) with 13C and 1H reveals a preserved complex interaction after both solubilizing and attenuating the HA-polyborate system. Stability of the product in water, low cost, ease of synthesis and scalability of manufacturing indicate that HA-polyborate complexes might have advantages over current chemotherapeutic approaches in creating therapeutic agents for BNCT. View Full-Text
Keywords: hyaluronic acid; borates; solid state synthesis; Fourier transform infrared spectroscopy; nuclear magnetic resonance; boron neutron capture therapy hyaluronic acid; borates; solid state synthesis; Fourier transform infrared spectroscopy; nuclear magnetic resonance; boron neutron capture therapy
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Zelenetskii, A.N.; Uspenskii, S.; Zaboronok, A.; Cherkaev, G.; Shchegolihin, A.; Mathis, B.J.; Selyanin, M.; Yamamoto, T.; Matsumura, A. Polycomplexes of Hyaluronic Acid and Borates in a Solid State and Solution: Synthesis, Characterization and Perspectives of Application in Boron Neutron Capture Therapy. Polymers 2018, 10, 181.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top