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Polymers 2018, 10(2), 106; https://doi.org/10.3390/polym10020106

Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion

1
The Russell Berrie Nanotechnology Institute, Technion—Israel Institute of Technology, Haifa 3200003, Israel
2
Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3200003, Israel
3
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa 3109601, Israel
4
Department of Chemical Engineering, Technion—Israel Institute of Technology, Haifa 3200003, Israel
*
Author to whom correspondence should be addressed.
Received: 26 December 2017 / Revised: 18 January 2018 / Accepted: 19 January 2018 / Published: 23 January 2018
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Abstract

The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and nanoparticle yield. Chitosan (CS) nanoparticles, serving as a control, were fabricated using the same procedure. The mucoadhesion of the nanoparticles was evaluated using the flow-through method after different incubation periods. The retention percentages of ACS nanoparticles were found to be significantly higher than those of CS nanoparticles, for all studied time intervals. An additional indication for the increased mucoadhesion of ACS nanoparticles was the increase in particle size obtained from the mucin particle method, in which mucin and nanoparticles are mixed at different ratios. NMR data verified the presence of free acrylate groups on the ACS nanoparticles. Thus, the improved mucoadhesion could be due to a Michael-type addition reaction between the nanoparticles and thiol groups present in mucin glycoprotein, in addition to entanglements and hydrogen bonding. Overall, ACS nanoparticles exhibit enhanced mucoadhesion properties as compared to CS nanoparticles and could be used as vehicles for drug delivery systems. View Full-Text
Keywords: chitosan; acrylated chitosan; nanoparticles; mucoadhesion; mucosal membranes; mucoadhesive polymers; retention chitosan; acrylated chitosan; nanoparticles; mucoadhesion; mucosal membranes; mucoadhesive polymers; retention
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Eliyahu, S.; Aharon, A.; Bianco-Peled, H. Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion. Polymers 2018, 10, 106.

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