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Crystals 2017, 7(10), 310; doi:10.3390/cryst7100310

Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields

Rostislaw Kaischew Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Academic Editor: Abel Moreno
Received: 22 September 2017 / Revised: 11 October 2017 / Accepted: 12 October 2017 / Published: 15 October 2017
(This article belongs to the Special Issue Protein Crystallization under the Presence of an Electric Field)
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Abstract

Three-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promote and direct protein crystallization so that crystals obtained are useful for X-ray studies. Application of electric fields aids control over protein crystal size and diffraction quality. Protein crystal nucleation and growth in the presence of electric fields are reviewed. A notion of mesoscopic level of impact on the protein crystallization exercised by an electric field is also considered. View Full-Text
Keywords: protein crystallization; classical and two-step nucleation mechanisms; impact of electric fields on the protein crystallization; external and internal electric fields; number density; size and quality of protein crystals protein crystallization; classical and two-step nucleation mechanisms; impact of electric fields on the protein crystallization; external and internal electric fields; number density; size and quality of protein crystals
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nanev, C.N. Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields. Crystals 2017, 7, 310.

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