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One-Pot Synthesis and Crystal Structure of Methyl 5-Hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan
Department of Inorganic and Analytical Chemistry, Universität Paderborn, Warburgerstr. 100, D-33098, Paderborn, Germany
* Author to whom correspondence should be addressed.
Received: 15 May 2012; in revised form: 31 July 2012 / Accepted: 14 August 2012 / Published: 27 August 2012
Abstract: The title compound, Methyl 5-Hydroxy-1-Phenyl-1H-Pyrazole-3-Carboxylate (C11H10N2O3), was prepared by a one-pot, two-component reaction of an equimolar mixture of phenyl hydrazine and dimethyl acetylene dicarboxylate (DMAD) at reflux temperature for 2 h in a mixture of toluene and dichloromethane as solvent. C11H10N2O3 was crystallized from an ethanol solution in monoclinic space group P21/c with unit cell dimensions a = 9.5408(16), b = 9.5827(16), c = 11.580(2) Å, β = 105.838(3)°, V = 1018.5(3) Å3, Z = 4.
Keywords: pyrazole; methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate; crystal structure
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MDPI and ACS Style
Saeed, A.; Arshad, I.; Flörke, U. One-Pot Synthesis and Crystal Structure of Methyl 5-Hydroxy-1-phenyl-1H-pyrazole-3-carboxylate. Crystals 2012, 2, 1248-1252.
Saeed A, Arshad I, Flörke U. One-Pot Synthesis and Crystal Structure of Methyl 5-Hydroxy-1-phenyl-1H-pyrazole-3-carboxylate. Crystals. 2012; 2(3):1248-1252.
Saeed, Aamer; Arshad, Ifzan; Flörke, Ulrich. 2012. "One-Pot Synthesis and Crystal Structure of Methyl 5-Hydroxy-1-phenyl-1H-pyrazole-3-carboxylate." Crystals 2, no. 3: 1248-1252.