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• Arshad, I
• Flörke, U
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Crystals 2012, 2(3), 1248-1252; doi:10.3390/cryst2031248

Short Note

One-Pot Synthesis and Crystal Structure of Methyl 5-Hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Aamer Saeed ^1,* , Ifzan Arshad ¹  and Ulrich Flörke ²

¹ Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan ² Department of Inorganic and Analytical Chemistry, Universität Paderborn, Warburgerstr. 100, D-33098, Paderborn, Germany

* Author to whom correspondence should be addressed.

Received: 15 May 2012; in revised form: 31 July 2012 / Accepted: 14 August 2012 / Published: 27 August 2012

Download PDF Full-Text [181 KB, uploaded 27 August 2012 09:52 CEST]

Abstract: The title compound, Methyl 5-Hydroxy-1-Phenyl-1H-Pyrazole-3-Carboxylate (C₁₁H₁₀N₂O₃), was prepared by a one-pot, two-component reaction of an equimolar mixture of phenyl hydrazine and dimethyl acetylene dicarboxylate (DMAD) at reflux temperature for 2 h in a mixture of toluene and dichloromethane as solvent. C₁₁H₁₀N₂O₃ was crystallized from an ethanol solution in monoclinic space group P2₁/c with unit cell dimensions a = 9.5408(16), b = 9.5827(16), c = 11.580(2) Å, β = 105.838(3)°, V = 1018.5(3) ų, Z = 4.

Keywords: pyrazole; methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate; crystal structure

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