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Catalysts 2018, 8(1), 4; https://doi.org/10.3390/catal8010004

Biosynthesis of Medium- to Long-Chain α,ω-Diols from Free Fatty Acids Using CYP153A Monooxygenase, Carboxylic Acid Reductase, and E. coli Endogenous Aldehyde Reductases

1
School of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
2
Department of Systems Biotechnology, Konkuk University, Seoul 050-29, Korea
*
Author to whom correspondence should be addressed.
Received: 27 November 2017 / Revised: 20 December 2017 / Accepted: 22 December 2017 / Published: 24 December 2017
(This article belongs to the Special Issue Biocatalysis and Biotransformations)
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Abstract

α,ω-Diols are important monomers widely used for the production of polyesters and polyurethanes. Here, biosynthesis of α,ω-diols (C8–C16) from renewable free fatty acids using CYP153A monooxygenase, carboxylic acid reductase, and E. coli endogenous aldehyde reductases is reported. The highest yield of α,ω-diol was achieved for the production of 1,12-dodecanediol. In the nicotinamide adenine dinucleotide phosphate (NADPH) cofactor regeneration system, 5 g/L of 1,12-dodecanediol was synthesized in 24 h reaction from the commercial ω-hydroxy dodecanoic acid. Finally, 1.4 g/L 1,12-dodecanediol was produced in a consecutive approach from dodecanoic acids. The results of this study demonstrated the scope of the potential development of bioprocesses to substitute the petroleum-based products in the polymer industry. View Full-Text
Keywords: carboxylic acid reductase; CYP153A monooxygenase; diols; polyester; polyurethanes carboxylic acid reductase; CYP153A monooxygenase; diols; polyester; polyurethanes
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Ahsan, M.M.; Sung, S.; Jeon, H.; Patil, M.D.; Chung, T.; Yun, H. Biosynthesis of Medium- to Long-Chain α,ω-Diols from Free Fatty Acids Using CYP153A Monooxygenase, Carboxylic Acid Reductase, and E. coli Endogenous Aldehyde Reductases. Catalysts 2018, 8, 4.

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