Chiral Catalyst Deactivation during the Asymmetric Hydrogenation of Acetophenone
AbstractAsymmetric hydrogenation in solution catalyzed by chiral catalysts is a powerful tool to obtain chiral secondary alcohols. It is possible to reach conversions and enantiomeric excesses close to 99%, but that frequently requires the use of non-optimal amounts of catalysts or long reaction times. That is in part caused by the lack of kinetic information needed for the design of large-scale reactors, including few reported details about catalyst deactivation. In this work, we present a kinetic model for the asymmetric hydrogenation in solution of acetophenone, a prochiral substrate, catalyzed by different bisphosphine-diamine Ru complexes. The experimental data was fitted with a first order model that includes first order deactivation of the catalyst and the presence of residual activity. The fit of the experimental data is very good, and an analysis of the kinetic and deactivation parameters gives further insight into the role of each ligand present in the Ru catalysts. This is the first report of a kinetic analysis of homogenous complexes’ catalysis including an analysis of their deactivation. View Full-Text
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Ruelas-Leyva, J.P.; Fuentes, G.A. Chiral Catalyst Deactivation during the Asymmetric Hydrogenation of Acetophenone. Catalysts 2017, 7, 193.
Ruelas-Leyva JP, Fuentes GA. Chiral Catalyst Deactivation during the Asymmetric Hydrogenation of Acetophenone. Catalysts. 2017; 7(7):193.Chicago/Turabian Style
Ruelas-Leyva, Jose P.; Fuentes, Gustavo A. 2017. "Chiral Catalyst Deactivation during the Asymmetric Hydrogenation of Acetophenone." Catalysts 7, no. 7: 193.
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