Conversion of Furans by Baeyer-Villiger Monooxygenases
AbstractVarious furans are considered as valuable platform chemicals as they can be derived from plant biomass. Yet, for their exploitation, follow-up chemistry is required. Here we demonstrate that Baeyer-Villiger monooxygenases (BVMOs) can be used as biocatalysts for the selective oxidation of several furans, including 5-(hydroxymethyl) furfural (HMF) and furfural. A total of 15 different BVMOs were tested for their activity on furfural, which revealed that most of the biocatalysts were active on this aromatic aldehyde. Phenylacetone monooxygenase (PAMO) and a mutant thereof (PAMOM446G) were selected for studying their biocatalytic potential in converting furfural and some other furans. While BVMOs are usually known to form an ester or lactone as a ‘normal’ product by inserting an oxygen atom adjacent to the carbonyl carbon of the substrate, our results reveal that both biocatalysts produce furanoid acids as the main product from the corresponding aldehydes. Altogether, our study shows that BVMOs can be employed for the selective oxidation of furans. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kumar, H.; Fraaije, M.W. Conversion of Furans by Baeyer-Villiger Monooxygenases. Catalysts 2017, 7, 179.
Kumar H, Fraaije MW. Conversion of Furans by Baeyer-Villiger Monooxygenases. Catalysts. 2017; 7(6):179.Chicago/Turabian Style
Kumar, Hemant; Fraaije, Marco W. 2017. "Conversion of Furans by Baeyer-Villiger Monooxygenases." Catalysts 7, no. 6: 179.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.