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Catalysts 2017, 7(6), 179; doi:10.3390/catal7060179

Conversion of Furans by Baeyer-Villiger Monooxygenases

Molecular Enzymology Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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Academic Editor: Manuel Ferrer
Received: 12 May 2017 / Revised: 30 May 2017 / Accepted: 2 June 2017 / Published: 7 June 2017
(This article belongs to the Special Issue Biocatalysis and Biotransformations)
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Abstract

Various furans are considered as valuable platform chemicals as they can be derived from plant biomass. Yet, for their exploitation, follow-up chemistry is required. Here we demonstrate that Baeyer-Villiger monooxygenases (BVMOs) can be used as biocatalysts for the selective oxidation of several furans, including 5-(hydroxymethyl) furfural (HMF) and furfural. A total of 15 different BVMOs were tested for their activity on furfural, which revealed that most of the biocatalysts were active on this aromatic aldehyde. Phenylacetone monooxygenase (PAMO) and a mutant thereof (PAMOM446G) were selected for studying their biocatalytic potential in converting furfural and some other furans. While BVMOs are usually known to form an ester or lactone as a ‘normal’ product by inserting an oxygen atom adjacent to the carbonyl carbon of the substrate, our results reveal that both biocatalysts produce furanoid acids as the main product from the corresponding aldehydes. Altogether, our study shows that BVMOs can be employed for the selective oxidation of furans. View Full-Text
Keywords: biocatalysis; Baeyer-Villiger monooxygenases; furfural; 5-hydroxymethyl furfural biocatalysis; Baeyer-Villiger monooxygenases; furfural; 5-hydroxymethyl furfural
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kumar, H.; Fraaije, M.W. Conversion of Furans by Baeyer-Villiger Monooxygenases. Catalysts 2017, 7, 179.

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