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Catalysts 2017, 7(5), 130; doi:10.3390/catal7050130

Old Yellow Enzyme-Catalysed Asymmetric Hydrogenation: Linking Family Roots with Improved Catalysis

1
Interdisciplinary Ecological Center, Institute of Biosciences, Environmental Microbiology Group, Technical University Bergakademie Freiberg, 09599 Freiberg, Germany
2
Laboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands
3
Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 Delft, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Cesar Mateo and Jose M. Palomo
Received: 16 March 2017 / Revised: 17 April 2017 / Accepted: 25 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Asymmetric and Selective Biocatalysis)
View Full-Text   |   Download PDF [5815 KB, uploaded 29 April 2017]   |  

Abstract

Asymmetric hydrogenation of activated alkenes catalysed by ene-reductases from the old yellow enzyme family (OYEs) leading to chiral products is of potential interest for industrial processes. OYEs’ dependency on the pyridine nucleotide coenzyme can be circumvented through established artificial hydride donors such as nicotinamide coenzyme biomimetics (NCBs). Several OYEs were found to exhibit higher reduction rates with NCBs. In this review, we describe a new classification of OYEs into three main classes by phylogenetic and structural analysis of characterized OYEs. The family roots are linked with their use as chiral catalysts and their mode of action with NCBs. The link between bioinformatics (sequence analysis), biochemistry (structure–function analysis), and biocatalysis (conversion, enantioselectivity and kinetics) can enable an early classification of a putative ene-reductase and therefore the indication of the binding mode of various activated alkenes. View Full-Text
Keywords: old yellow enzymes; nicotinamide coenzyme biomimetics; cofactor analogues; classification of OYE; oxidoreductases; asymmetric hydrogenation; selective reduction; phylogenetics old yellow enzymes; nicotinamide coenzyme biomimetics; cofactor analogues; classification of OYE; oxidoreductases; asymmetric hydrogenation; selective reduction; phylogenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Scholtissek, A.; Tischler, D.; Westphal, A.H.; van Berkel, W.J.H.; Paul, C.E. Old Yellow Enzyme-Catalysed Asymmetric Hydrogenation: Linking Family Roots with Improved Catalysis. Catalysts 2017, 7, 130.

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