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Catalysts 2017, 7(12), 387; doi:10.3390/catal7120387

Catalytic Enantioselective Addition of Me2Zn to Isatins

Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner 50, Burjassot 46100 (València), Spain
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Received: 15 November 2017 / Revised: 7 December 2017 / Accepted: 8 December 2017 / Published: 13 December 2017
(This article belongs to the Special Issue Catalyzed Synthesis of Natural Products)
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Abstract

Chiral α-hydroxyamide L5 derived from (S)-(+)-mandelic acid catalyzes the enantioselective addition of dimethylzinc to isatins affording the corresponding chiral 3-hydroxy-3-methyl-2-oxindoles with good yields and er up to 90:10. Furthermore, several chemical transformations were performed with the 3-hydroxy-2-oxindoles obtained. View Full-Text
Keywords: asymmetric catalysis; isatin; 3-hydroxyoxindole; zinc; mandelamides; chiral α-hydroxyamide asymmetric catalysis; isatin; 3-hydroxyoxindole; zinc; mandelamides; chiral α-hydroxyamide
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Vila, C.; del Campo, A.; Blay, G.; Pedro, J.R. Catalytic Enantioselective Addition of Me2Zn to Isatins. Catalysts 2017, 7, 387.

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