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Catalysts 2017, 7(12), 387; doi:10.3390/catal7120387

Catalytic Enantioselective Addition of Me2Zn to Isatins

Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner 50, Burjassot 46100 (València), Spain
Authors to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 7 December 2017 / Accepted: 8 December 2017 / Published: 13 December 2017
(This article belongs to the Special Issue Catalyzed Synthesis of Natural Products)
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Chiral α-hydroxyamide L5 derived from (S)-(+)-mandelic acid catalyzes the enantioselective addition of dimethylzinc to isatins affording the corresponding chiral 3-hydroxy-3-methyl-2-oxindoles with good yields and er up to 90:10. Furthermore, several chemical transformations were performed with the 3-hydroxy-2-oxindoles obtained. View Full-Text
Keywords: asymmetric catalysis; isatin; 3-hydroxyoxindole; zinc; mandelamides; chiral α-hydroxyamide asymmetric catalysis; isatin; 3-hydroxyoxindole; zinc; mandelamides; chiral α-hydroxyamide

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vila, C.; del Campo, A.; Blay, G.; Pedro, J.R. Catalytic Enantioselective Addition of Me2Zn to Isatins. Catalysts 2017, 7, 387.

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