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Catalysts 2016, 6(12), 194; doi:10.3390/catal6120194

Tandem Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
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Author to whom correspondence should be addressed.
Academic Editors: Jose M. Palomo and Cesar Mateo
Received: 7 November 2016 / Revised: 28 November 2016 / Accepted: 29 November 2016 / Published: 5 December 2016
(This article belongs to the Special Issue Asymmetric and Selective Biocatalysis)
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Abstract

The application of biocatalysts in the synthesis of fine chemicals and medicinal compounds has grown significantly in recent years. Particularly, there is a growing interest in the development of one-pot tandem catalytic systems combining the reactivity of a chemical catalyst with the selectivity engendered by the active site of an enzyme. Such tandem catalytic systems can achieve levels of chemo-, regio-, and stereo-selectivities that are unattainable with a small molecule catalyst. In addition, artificial metalloenzymes widen the range of reactivities and catalyzed reactions that are potentially employable. This review highlights some of the recent examples in the past three years that combined transition metal catalysis with enzymatic catalysis. This field is still in its infancy. However, with recent advances in protein engineering, catalyst synthesis, artificial metalloenzymes and supramolecular assembly, there is great potential to develop more sophisticated tandem chemoenzymatic processes for the synthesis of structurally complex chemicals. View Full-Text
Keywords: tandem catalysis; chemoenzymatic; biocatalysis; dynamic kinetic resolution; artificial metalloenzyme; asymmetric synthesis tandem catalysis; chemoenzymatic; biocatalysis; dynamic kinetic resolution; artificial metalloenzyme; asymmetric synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, Y.; Zhao, H. Tandem Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis. Catalysts 2016, 6, 194.

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