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Cancers 2017, 9(9), 111; https://doi.org/10.3390/cancers9090111

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
Academic Editor: Samuel C. Mok
Received: 28 July 2017 / Revised: 24 August 2017 / Accepted: 24 August 2017 / Published: 29 August 2017
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Abstract

Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge. View Full-Text
Keywords: ALK; fusion; kidney; renal cell carcinoma; TFE3; TFEB; translocation ALK; fusion; kidney; renal cell carcinoma; TFE3; TFEB; translocation
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Inamura, K. Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features. Cancers 2017, 9, 111.

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