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Cancers 2017, 9(7), 85; doi:10.3390/cancers9070085

The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas

Department of Radiation Oncology, the Ohio State University Comprehensive Cancer Center & Arthur, G. James Cancer Hospital, Columbus, OH 43012, USA
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Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 31 May 2017 / Revised: 1 July 2017 / Accepted: 3 July 2017 / Published: 10 July 2017
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Abstract

MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The dysregulation of miRNA plays a pivotal role in cancer tumorigenesis, including the development and progression of gliomas. Their small size, stability and ability to target multiple oncogenes have simultaneously distinguished miRNAs as attractive candidates for biomarkers and novel therapeutic targets for glioma patients. In this review, we summarize the most frequently cited miRNAs known to contribute to gliomagenesis and progression by regulating the defining hallmarks of gliomas, including angiogenesis, invasion, and cell metabolism. We also discuss their promising potential as prognostic and predictive biomarkers and novel therapeutic targets, in addition to the challenges that must be overcome before their translation from bench to bedside. View Full-Text
Keywords: glioma; glioblastoma; miRNA; angiogenesis; invasion; cell metabolism glioma; glioblastoma; miRNA; angiogenesis; invasion; cell metabolism
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MDPI and ACS Style

Beyer, S.; Fleming, J.; Meng, W.; Singh, R.; Haque, S.J.; Chakravarti, A. The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas. Cancers 2017, 9, 85.

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