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Cancers 2017, 9(6), 56; doi:10.3390/cancers9060056

RGD-Binding Integrins in Head and Neck Cancers

1
Radiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia
2
Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 21 April 2017 / Revised: 22 May 2017 / Accepted: 23 May 2017 / Published: 26 May 2017
(This article belongs to the Special Issue Integrins in Cancer)
View Full-Text   |   Download PDF [257 KB, uploaded 26 May 2017]

Abstract

Alterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide range of integrin receptors. Expression of the αv and β1 subunits has been explored relatively extensively and linked to tumour progression and metastasis. Individual receptors αvβ3 and αvβ5 have proved popular targets for diagnostic and therapeutic agents but lesser studied receptors, such as αvβ6, αvβ8, and β1 subfamily members, also show promise. This review presents the current knowledge of integrin expression and function in squamous cell carcinoma of the head and neck (HNSCC), with a particular focus on the arginine-glycine-aspartate (RGD)-binding integrins, in order to highlight the potential of integrins as targets for personalised tumour-specific identification and therapy. View Full-Text
Keywords: integrin αv; β1; β3; β6; arginine-glycine-aspartate (RGD); metastasis; treatment resistance integrin αv; β1; β3; β6; arginine-glycine-aspartate (RGD); metastasis; treatment resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ahmedah, H.T.; Patterson, L.H.; Shnyder, S.D.; Sheldrake, H.M. RGD-Binding Integrins in Head and Neck Cancers. Cancers 2017, 9, 56.

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