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Cancers 2017, 9(2), 20; doi:10.3390/cancers9020020

Androgen Receptor Signaling in Bladder Cancer

1,2,3
,
4,5,6
and
1,2,4,5,7,*
1
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
2
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
3
Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
4
Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
5
James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
6
Department of Urology, Xiangya Hospital of Central South University, Changsha 410008, China
7
Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel S. Antonarakis
Received: 1 December 2016 / Revised: 24 January 2017 / Accepted: 16 February 2017 / Published: 22 February 2017
(This article belongs to the Special Issue AR Signaling in Human Malignancies: Prostate Cancer and Beyond)
View Full-Text   |   Download PDF [483 KB, uploaded 22 February 2017]   |  

Abstract

Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor development and progression, which may clearly explain some sex-specific differences in bladder cancer. This review summarizes and discusses the available data, suggesting the involvement of androgens and/or the androgen receptor pathways in urothelial carcinogenesis as well as tumor growth. While the precise mechanisms of the functions of the androgen receptor in urothelial cells remain far from being fully understood, current evidence may offer chemopreventive or therapeutic options, using androgen deprivation therapy, in patients with bladder cancer. View Full-Text
Keywords: androgen; androgen receptor; anti-androgen; carcinogenesis; tumor progression; urothelial cancer androgen; androgen receptor; anti-androgen; carcinogenesis; tumor progression; urothelial cancer
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Li, P.; Chen, J.; Miyamoto, H. Androgen Receptor Signaling in Bladder Cancer. Cancers 2017, 9, 20.

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