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Cancers 2017, 9(11), 153; doi:10.3390/cancers9110153

Role of LFA-1 and ICAM-1 in Cancer

1,2,* and 1,2,*
1
Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain
2
Celltec UB, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Helen M. Sheldrake
Received: 22 August 2017 / Revised: 23 October 2017 / Accepted: 23 October 2017 / Published: 3 November 2017
(This article belongs to the Special Issue Integrins in Cancer)
View Full-Text   |   Download PDF [263 KB, uploaded 3 November 2017]

Abstract

The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ2), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia. Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis. View Full-Text
Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Reina, M.; Espel, E. Role of LFA-1 and ICAM-1 in Cancer. Cancers 2017, 9, 153.

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