Radioresistance of Brain Tumors
AbstractRadiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation. View Full-Text
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Kelley, K.; Knisely, J.; Symons, M.; Ruggieri, R. Radioresistance of Brain Tumors. Cancers 2016, 8, 42.
Kelley K, Knisely J, Symons M, Ruggieri R. Radioresistance of Brain Tumors. Cancers. 2016; 8(4):42.Chicago/Turabian Style
Kelley, Kevin; Knisely, Jonathan; Symons, Marc; Ruggieri, Rosamaria. 2016. "Radioresistance of Brain Tumors." Cancers 8, no. 4: 42.
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