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Cancers 2016, 8(3), 32; doi:10.3390/cancers8030032

South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy

1
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar Tamilnadu 608002, India
2
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Zhe-Sheng (Jason) Chen
Received: 18 January 2016 / Revised: 5 February 2016 / Accepted: 29 February 2016 / Published: 5 March 2016
(This article belongs to the Special Issue Drug/Radiation Resistance in Cancer Therapy)
View Full-Text   |   Download PDF [1765 KB, uploaded 5 March 2016]   |  

Abstract

Cancer is a hyperproliferative disorder that involves transformation, dysregulation of apoptosis, proliferation, invasion, angiogenesis and metastasis. During the last 30 years, extensive research has revealed much about the biology of cancer. Chemotherapy and radiotherapy are the mainstays of cancer treatment, particularly for patients who do not respond to surgical resection. However, cancer treatment with drugs or radiation is seriously limited by chemoresistance and radioresistance. Various approaches and strategies are employed to overcome resistance to chemotherapy and radiation treatment. Many plant-derived phytochemicals have been investigated for their chemo- and radio-sensitizing properties. The peoples of South Asian countries such as India, Pakistan, Sri Lanka, Nepal, Bangladesh and Bhutan have a large number of medicinal plants from which they produce various pharmacologically potent secondary metabolites. The medicinal properties of these compounds have been extensively investigated and many of them have been found to sensitize cancer cells to chemo- and radio-therapy. This review focuses on the role of South Asian medicinal compounds in chemo- and radio-sensitizing properties in drug- and radio-resistant cancer cells. Also discussed is the role of South Asian medicinal plants in protecting normal cells from radiation, which may be useful during radiotherapy of tumors to spare surrounding normal cells. View Full-Text
Keywords: South Asian plants; ABC transporter; chemoresistance; radioresistance; phytochemicals South Asian plants; ABC transporter; chemoresistance; radioresistance; phytochemicals
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Prasad, N.R.; Muthusamy, G.; Shanmugam, M.; Ambudkar, S.V. South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy. Cancers 2016, 8, 32.

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