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Cancers 2016, 8(2), 24; doi:10.3390/cancers8020024

The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis

Department of Otolaryngology—Head and Neck Surgery, University of Southern California, 1450 San Pablo St, Suite 5100, Los Angeles, CA 90033, USA
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Academic Editor: David Wong
Received: 7 September 2015 / Revised: 7 February 2016 / Accepted: 16 February 2016 / Published: 19 February 2016
View Full-Text   |   Download PDF [202 KB, uploaded 19 February 2016]

Abstract

The cancer stem cell (CSC) theory proposes that a minority of tumor cells are capable of self-replication and tumorigenesis. It is these minority of cells that are responsible for cancer metastasis and recurrence in head and neck squamous cell cancers (HNSCC). Human papilloma virus (HPV)-related cancer of the oropharynx is becoming more prevalent, which makes understanding of the relationship between HPV and CSCs more important than ever. This relationship is critical because CSC behavior can be predicted based on cell surface markers, which makes them a suitable candidate for targeted therapy. New therapies are an exciting opportunity to advance past the stalled outcomes in HNSCC that have plagued patients and clinicians for several decades. View Full-Text
Keywords: cancer stem cell; cancer initiating cell; human papilloma virus; HPV; Notch; Oct-4; Nanog cancer stem cell; cancer initiating cell; human papilloma virus; HPV; Notch; Oct-4; Nanog
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Swanson, M.S.; Kokot, N.; Sinha, U.K. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers 2016, 8, 24.

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