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Cancers 2016, 8(11), 102; doi:10.3390/cancers8110102

Advance Care Planning in Glioblastoma Patients

1
Department of Neurology, Haaglanden Medical Center, P.O. BOX 432, 2501 CK The Hague, The Netherlands
2
Department of Neurology, Leiden University Medical Center, P.O. BOX 9600, 2300 RC Leiden, The Netherlands
3
Department of Neurology, VU University Medical Center, P.O. BOX 7057, 1007 MB Amsterdam, The Netherlands
4
Department of Neurology, Academic Medical Center, P.O. BOX 22660, 1100 DD Amsterdam, The Netherlands
5
Department of Medical Decision Making/Quality of Care, Leiden University Medical Center, P.O. BOX 9600, 2300 RC Leiden, The Netherlands
6
Department of Public and Occupational Health, VU University Medical Center, P.O. BOX 7057, 1007 MB Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Gregory Crawford
Received: 1 September 2016 / Revised: 20 October 2016 / Accepted: 2 November 2016 / Published: 8 November 2016
(This article belongs to the Special Issue End-of-Life Cancer Care)
View Full-Text   |   Download PDF [204 KB, uploaded 8 November 2016]

Abstract

Despite multimodal treatment with surgery, radiotherapy and chemotherapy, glioblastoma is an incurable disease with a poor prognosis. During the disease course, glioblastoma patients may experience progressive neurological deficits, symptoms of increased intracranial pressure such as drowsiness and headache, incontinence, seizures and progressive cognitive dysfunction. These patients not only have cancer, but also a progressive brain disease. This may seriously interfere with their ability to make their own decisions regarding treatment. It is therefore warranted to involve glioblastoma patients early in the disease trajectory in treatment decision-making on their future care, including the end of life (EOL) care, which can be achieved with Advance Care Planning (ACP). Although ACP, by definition, aims at timely involvement of patients and proxies in decision-making on future care, the optimal moment to initiate ACP discussions in the disease trajectory of glioblastoma patients remains controversial. Moreover, the disease-specific content of these ACP discussions needs to be established. In this article, we will first describe the history of patient participation in treatment decision-making, including the shift towards ACP. Secondly, we will describe the possible role of ACP for glioblastoma patients, with the specific aim of treatment of disease-specific symptoms such as somnolence and dysphagia, epileptic seizures, headache, and personality changes, agitation and delirium in the EOL phase, and the importance of timing of ACP discussions in this patient population. View Full-Text
Keywords: glioblastoma; advance care planning; decision-making; end-of-life; palliative care glioblastoma; advance care planning; decision-making; end-of-life; palliative care
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fritz, L.; Dirven, L.; Reijneveld, J.C.; Koekkoek, J.A.F.; Stiggelbout, A.M.; Pasman, H.R.W.; Taphoorn, M.J.B. Advance Care Planning in Glioblastoma Patients. Cancers 2016, 8, 102.

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