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Cancers 2015, 7(4), 2466-2485;

Oncogenic MicroRNAs: Key Players in Malignant Transformation

Translational Oncogenomics Laboratory, Regina Elena National Cancer Institute, 00144 Rome, Italy
Author to whom correspondence should be addressed.
Academic Editor: Charles H. Lawrie
Received: 2 September 2015 / Revised: 2 December 2015 / Accepted: 11 December 2015 / Published: 18 December 2015
(This article belongs to the Special Issue Non-Coding RNAs in Cancers)
Full-Text   |   PDF [825 KB, uploaded 18 December 2015]   |  


MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy. View Full-Text
Keywords: cancer; oncogenic miRNAs; cell cycle regulation; apoptosis cancer; oncogenic miRNAs; cell cycle regulation; apoptosis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Frixa, T.; Donzelli, S.; Blandino, G. Oncogenic MicroRNAs: Key Players in Malignant Transformation. Cancers 2015, 7, 2466-2485.

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