Next Article in Journal
Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy
Next Article in Special Issue
Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
Previous Article in Journal
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance
Previous Article in Special Issue
Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer
Article Menu

Export Article

Open AccessCommentary
Cancers 2015, 7(4), 2352-2359; doi:10.3390/cancers7040896

The Microenvironment in Gliomas: Phenotypic Expressions

Research Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 20 October 2015 / Revised: 25 November 2015 / Accepted: 27 November 2015 / Published: 3 December 2015
(This article belongs to the Special Issue Cancer Stem Cells and Tumor Microenvironment)
View Full-Text   |   Download PDF [1265 KB, uploaded 3 December 2015]   |  

Abstract

The microenvironment of malignant gliomas is described according to its definition in the literature. Beside tumor cells, a series of stromal cells (microglia/macrophages, pericytes, fibroblasts, endothelial cells, normal and reactive astrocytes) represents the cell component, whereas a complex network of molecular signaling represents the functional component. Its most evident expressions are perivascular and perinecrotic niches that are believed to be the site of tumor stem cells or progenitors in the tumor. Phenotypically, both niches are not easily recognizable; here, they are described together with a critical revision of their concept. As for perinecrotic niches, an alternative interpretation is given about their origin that regards the tumor stem cells as the residue of those that populated hyperproliferating areas in which necroses develop. This is based on the concept that the stem-like is a status and not a cell type, depending on the microenvironment that regulates a conversion of tumor non-stem cells and tumor stem cells through a cell reprogramming. View Full-Text
Keywords: stem cells; microenvironment; niches stem cells; microenvironment; niches
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Schiffer, D.; Annovazzi, L.; Mazzucco, M.; Mellai, M. The Microenvironment in Gliomas: Phenotypic Expressions. Cancers 2015, 7, 2352-2359.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top