Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling
AbstractDiscussions of therapeutic suppression of hedgehog (Hh) signaling almost exclusively focus on receptor antagonism; however, hedgehog’s biosynthesis represents a unique and potentially targetable aspect of this oncogenic signaling pathway. Here, we review a key biosynthetic step called cholesterolysis from the perspectives of structure/function and small molecule inhibition. Cholesterolysis, also called cholesteroylation, generates cholesterol-modified Hh ligand via autoprocessing of a hedgehog precursor protein. Post-translational modification by cholesterol appears to be restricted to proteins in the hedgehog family. The transformation is essential for Hh biological activity and upstream of signaling events. Despite its decisive role in generating ligand, cholesterolysis remains conspicuously unexplored as a therapeutic target. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Callahan, B.P.; Wang, C. Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling. Cancers 2015, 7, 2037-2053.
Callahan BP, Wang C. Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling. Cancers. 2015; 7(4):2037-2053.Chicago/Turabian Style
Callahan, Brian P.; Wang, Chunyu. 2015. "Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling." Cancers 7, no. 4: 2037-2053.