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Cancers 2015, 7(3), 1484-1498;

Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis

Department of Pediatrics, Division of Hematology/Oncology, Washington University in St. Louis School of Medicine, Campus Box 8208, 660 South Euclid Ave, St. Louis, MO 63110, USA
Author to whom correspondence should be addressed.
Academic Editor: Hui-Wen Lo
Received: 30 June 2015 / Revised: 30 July 2015 / Accepted: 3 August 2015 / Published: 6 August 2015
View Full-Text   |   Download PDF [482 KB, uploaded 6 August 2015]   |  


The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies. View Full-Text
Keywords: Sonic hedgehog; cerebellum; medulloblastoma; GPCR; signal transduction Sonic hedgehog; cerebellum; medulloblastoma; GPCR; signal transduction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ward, S.A.; Rubin, J.B. Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis. Cancers 2015, 7, 1484-1498.

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