Next Article in Journal
Molecular Targeted Intervention for Pancreatic Cancer
Next Article in Special Issue
Hedgehog Signaling in the Maintenance of Cancer Stem Cells
Previous Article in Journal
Breast Cancer in Elderly Caucasian Women—An Institution-Based Study of Correlation between Breast Cancer Prognostic Markers, TNM Stage, and Overall Survival
Previous Article in Special Issue
The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer
Article Menu

Export Article

Open AccessReview
Cancers 2015, 7(3), 1484-1498; doi:10.3390/cancers7030848

Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis

Department of Pediatrics, Division of Hematology/Oncology, Washington University in St. Louis School of Medicine, Campus Box 8208, 660 South Euclid Ave, St. Louis, MO 63110, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Hui-Wen Lo
Received: 30 June 2015 / Revised: 30 July 2015 / Accepted: 3 August 2015 / Published: 6 August 2015
View Full-Text   |   Download PDF [482 KB, uploaded 6 August 2015]   |  

Abstract

The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies. View Full-Text
Keywords: Sonic hedgehog; cerebellum; medulloblastoma; GPCR; signal transduction Sonic hedgehog; cerebellum; medulloblastoma; GPCR; signal transduction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ward, S.A.; Rubin, J.B. Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis. Cancers 2015, 7, 1484-1498.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top