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Cancers 2015, 7(3), 1436-1446; doi:10.3390/cancers7030847

Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia

Division of Gastroenterology and Hepatology, Veterans Administration Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Author to whom correspondence should be addressed.
Academic Editor: Hiromi I. Wettersten
Received: 8 June 2015 / Revised: 27 July 2015 / Accepted: 29 July 2015 / Published: 31 July 2015
View Full-Text   |   Download PDF [450 KB, uploaded 31 July 2015]   |  

Abstract

For both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC. View Full-Text
Keywords: colorectal cancer; TCDD; aryl hydrocarbon receptor; xenobiotics colorectal cancer; TCDD; aryl hydrocarbon receptor; xenobiotics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xie, G.; Raufman, J.-P. Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia. Cancers 2015, 7, 1436-1446.

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