Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia
AbstractFor both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC. View Full-Text
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Xie, G.; Raufman, J.-P. Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia. Cancers 2015, 7, 1436-1446.
Xie G, Raufman J-P. Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia. Cancers. 2015; 7(3):1436-1446.Chicago/Turabian Style
Xie, Guofeng; Raufman, Jean-Pierre. 2015. "Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia." Cancers 7, no. 3: 1436-1446.