Next Article in Journal
Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
Previous Article in Journal
Claudin11 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin, but Uncommon in Nevus Cell Nevi
Previous Article in Special Issue
Chromatinization of the KSHV Genome During the KSHV Life Cycle
Article Menu

Export Article

Open AccessReview
Cancers 2015, 7(3), 1244-1270; doi:10.3390/cancers7030835

Human BK Polyomavirus—The Potential for Head and Neck Malignancy and Disease

1
Microbiology and Immunology Department, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2
Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Elena Kashuba
Received: 14 May 2015 / Revised: 25 June 2015 / Accepted: 25 June 2015 / Published: 8 July 2015
(This article belongs to the Special Issue DNA Viruses in Human Cancer)
View Full-Text   |   Download PDF [550 KB, uploaded 8 July 2015]   |  

Abstract

Members of the human Polyomaviridae family are ubiquitous and pathogenic among immune-compromised individuals. While only Merkel cell polyomavirus (MCPyV) has conclusively been linked to human cancer, all members of the polyomavirus (PyV) family encode the oncoprotein T antigen and may be potentially carcinogenic. Studies focusing on PyV pathogenesis in humans have become more abundant as the number of PyV family members and the list of associated diseases has expanded. BK polyomavirus (BKPyV) in particular has emerged as a new opportunistic pathogen among HIV positive individuals, carrying harmful implications. Increasing evidence links BKPyV to HIV-associated salivary gland disease (HIVSGD). HIVSGD is associated with elevated risk of lymphoma formation and its prevalence has increased among HIV/AIDS patients. Determining the relationship between BKPyV, disease and tumorigenesis among immunosuppressed individuals is necessary and will allow for expanding effective anti-viral treatment and prevention options in the future. View Full-Text
Keywords: polyomavirus; cancer; BK polyomavirus; HIV-associated salivary gland disease polyomavirus; cancer; BK polyomavirus; HIV-associated salivary gland disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Burger-Calderon, R.; Webster-Cyriaque, J. Human BK Polyomavirus—The Potential for Head and Neck Malignancy and Disease. Cancers 2015, 7, 1244-1270.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top