The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma
AbstractNeuroblastoma is the second most common paediatric cancer. It developsfrom undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, theaetiology behind the development of neuroblastoma is still not fully understood. Intracellularcalcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processesand, therefore, its concentration is tightly regulated. This review focuses on the role of[Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes themechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways.Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminatedin this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatmentin neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosisin cancer cells leading to a more efficient and effective treatment of neuroblastoma. View Full-Text
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Satheesh, N.J.; Büsselberg, D. The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma. Cancers 2015, 7, 823-848.
Satheesh NJ, Büsselberg D. The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma. Cancers. 2015; 7(2):823-848.Chicago/Turabian Style
Satheesh, Noothan J.; Büsselberg, Dietrich. 2015. "The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma." Cancers 7, no. 2: 823-848.