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Cancers 2015, 7(2), 823-848; doi:10.3390/cancers7020811

The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma

Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, POB 24144, Doha, Qatar
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Author to whom correspondence should be addressed.
Academic Editor: Hiromi I. Wettersten
Received: 22 March 2015 / Accepted: 5 May 2015 / Published: 22 May 2015
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Abstract

Neuroblastoma is the second most common paediatric cancer. It developsfrom undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, theaetiology behind the development of neuroblastoma is still not fully understood. Intracellularcalcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processesand, therefore, its concentration is tightly regulated. This review focuses on the role of[Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes themechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways.Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminatedin this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatmentin neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosisin cancer cells leading to a more efficient and effective treatment of neuroblastoma. View Full-Text
Keywords: neuroblastoma; intracellular calcium([Ca2+]i); PI3K/AKT; ALK; FAK; NGF signalling; differentiation; apoptosis; proliferation; chemotherapeutic treatment; chemotherapy; drug resistance neuroblastoma; intracellular calcium([Ca2+]i); PI3K/AKT; ALK; FAK; NGF signalling; differentiation; apoptosis; proliferation; chemotherapeutic treatment; chemotherapy; drug resistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Satheesh, N.J.; Büsselberg, D. The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma. Cancers 2015, 7, 823-848.

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