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Cancers 2014, 6(3), 1441-1463; doi:10.3390/cancers6031441
Review

The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma

1
 and 1,2,*
Received: 14 April 2014; in revised form: 24 June 2014 / Accepted: 26 June 2014 / Published: 7 July 2014
(This article belongs to the Special Issue Kinases and Cancer)
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Abstract: The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this pathway is an important promoter of cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in the PI3K/Akt/mTOR pathway in gastric carcinoma have often been demonstrated. Many kinds of molecular targeting therapies are currently undergoing clinical testing in patients with solid tumors. However, with the exception of the ErbB2-targeting antibody, targeting agents, including PI3K/Akt/mTOR inhibitors, have not been approved for treatment of patients with gastric carcinoma. This review summarizes the current knowledge on PI3K/Akt/mTOR signaling in the pathogenesis of gastric carcinoma and the possible therapeutic targets for gastric carcinoma. Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric carcinoma.
Keywords: PI3K/Akt/mTOR pathway; gastric carcinoma; target therapy; apoptosis; matastasis; chemo-resistance PI3K/Akt/mTOR pathway; gastric carcinoma; target therapy; apoptosis; matastasis; chemo-resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Matsuoka, T.; Yashiro, M. The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. Cancers 2014, 6, 1441-1463.

AMA Style

Matsuoka T, Yashiro M. The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. Cancers. 2014; 6(3):1441-1463.

Chicago/Turabian Style

Matsuoka, Tasuku; Yashiro, Masakazu. 2014. "The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma." Cancers 6, no. 3: 1441-1463.



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