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Cancers 2014, 6(3), 1363-1381; doi:10.3390/cancers6031363

Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma

1
Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, Belgium
2
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Medical School, Bari I-70124, Italy
3
Stem Cell Laboratory, Division of Clinical Hematology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels 1090, Belgium
4
Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari Medical School, Bari I-70124, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 17 March 2014 / Accepted: 4 June 2014 / Published: 27 June 2014
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Abstract

Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease. View Full-Text
Keywords: multiple myeloma; hypoxia; cancer associated fibroblasts multiple myeloma; hypoxia; cancer associated fibroblasts
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

De Veirman, K.; Rao, L.; De Bruyne, E.; Menu, E.; Van Valckenborgh, E.; Van Riet, I.; Frassanito, M.A.; Di Marzo, L.; Vacca, A.; Vanderkerken, K. Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma. Cancers 2014, 6, 1363-1381.

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