Cancers 2014, 6(2), 646-662; doi:10.3390/cancers6020646
Review

Stat3 and Gap Junctions in Normal and Lung Cancer Cells

1,†email, 2,†,‡email, 1,§email and 1,2,* email
Received: 14 November 2013; in revised form: 11 February 2014 / Accepted: 27 February 2014 / Published: 25 March 2014
(This article belongs to the Special Issue STAT3 Signalling in Cancer: Friend or Foe)
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Abstract: Gap junctions are channels linking the interiors of neighboring cells. A reduction in gap junctional intercellular communication (GJIC) correlates with high cell proliferation, while oncogene products such as Src suppress GJIC, through the Ras/Raf/Erk and other effector pathways. High Src activity was found to correlate with high levels of the Src effector, Signal Transducer and Activator of Transcription-3 (Stat3) in its tyrosine-705 phosphorylated, i.e., transcriptionally activated form, in the majority of Non-Small Cell Lung Cancer lines examined. However, Stat3 inhibition did not restore GJIC in lines with high Src activity. In the contrary, Stat3 inhibition in normal cells or in lines with low Src activity and high GJIC eliminated gap junctional communication. Therefore, despite the fact that Stat3 is growth promoting and in an activated form acts like an oncogene, it is actually required for junctional permeability.
Keywords: signal transducer and activator of transcription-3; gap junctions; connexin43
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Guy, S.; Geletu, M.; Arulanandam, R.; Raptis, L. Stat3 and Gap Junctions in Normal and Lung Cancer Cells. Cancers 2014, 6, 646-662.

AMA Style

Guy S, Geletu M, Arulanandam R, Raptis L. Stat3 and Gap Junctions in Normal and Lung Cancer Cells. Cancers. 2014; 6(2):646-662.

Chicago/Turabian Style

Guy, Stephanie; Geletu, Mulu; Arulanandam, Rozanne; Raptis, Leda. 2014. "Stat3 and Gap Junctions in Normal and Lung Cancer Cells." Cancers 6, no. 2: 646-662.



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