Next Article in Journal
Oxidative Stress in the Carcinogenicity of Chemical Carcinogens
Next Article in Special Issue
Immune-Checkpoint Blockade and Active Immunotherapy for Glioma
Previous Article in Journal / Special Issue
Strategies in Gene Therapy for Glioblastoma
Article Menu

Export Article

Open AccessReview
Cancers 2013, 5(4), 1306-1331; doi:10.3390/cancers5041306

MicroRNA in Human Glioma

1,2,* , 1,3
,
1,2
,
1,2
,
1,4
and
1,5
1
Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080, China
2
Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
3
Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
4
Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
5
Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China
*
Author to whom correspondence should be addressed.
Received: 22 September 2013 / Revised: 8 October 2013 / Accepted: 10 October 2013 / Published: 23 October 2013
(This article belongs to the Special Issue Glioblastoma)
View Full-Text   |   Download PDF [540 KB, uploaded 23 October 2013]

Abstract

Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy.
Keywords: glioma; microRNA; biological function; gap filler; amplifier; crosstalk; biomarker glioma; microRNA; biological function; gap filler; amplifier; crosstalk; biomarker
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, M.; Li, J.; Liu, L.; Li, W.; Yang, Y.; Yuan, J. MicroRNA in Human Glioma. Cancers 2013, 5, 1306-1331.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top