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Cancers 2013, 5(2), 591-616; doi:10.3390/cancers5020591
Review

Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

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Received: 22 March 2013 / Revised: 28 April 2013 / Accepted: 9 May 2013 / Published: 24 May 2013
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Abstract

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies.
Keywords: osteosarcoma; chemotherapy; surgery; radiotherapy; multidisciplinary treatment; emerging drugs osteosarcoma; chemotherapy; surgery; radiotherapy; multidisciplinary treatment; emerging drugs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ando, K.; Heymann, M.-F.; Stresing, V.; Mori, K.; Rédini, F.; Heymann, D. Current Therapeutic Strategies and Novel Approaches in Osteosarcoma. Cancers 2013, 5, 591-616.

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