Next Article in Journal
99mTc-HYNIC-Annexin A5 in Oncology: Evaluating Efficacy of Anti-Cancer Therapies
Next Article in Special Issue
Head and Neck Sarcomas: A Comprehensive Cancer Center Experience
Previous Article in Journal / Special Issue
Lost in Translation: Ambiguity in Nerve Sheath Tumor Nomenclature and Its Resultant Treatment Effect
Cancers 2013, 5(2), 529-549; doi:10.3390/cancers5020529
Review

Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results

1
,
2
,
3
,
4
 and
1,4,*
1 Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 2 Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 3 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 4 Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
* Author to whom correspondence should be addressed.
Received: 21 March 2013 / Revised: 16 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
View Full-Text   |   Download PDF [362 KB, uploaded 10 May 2013]   |   Browse Figure

Abstract

Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging.
Keywords: liposarcoma; chemotherapy; molecular-based therapy; clinical trials liposarcoma; chemotherapy; molecular-based therapy; clinical trials
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Tseng, W.W.; Somaiah, N.; Lazar, A.J.; Lev, D.C.; Pollock, R.E. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers 2013, 5, 529-549.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert