Abstract: Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging.
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Tseng, W.W.; Somaiah, N.; Lazar, A.J.; Lev, D.C.; Pollock, R.E. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers 2013, 5, 529-549.
Tseng WW, Somaiah N, Lazar AJ, Lev DC, Pollock RE. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers. 2013; 5(2):529-549.
Tseng, William W.; Somaiah, Neeta; Lazar, Alexander J.; Lev, Dina C.; Pollock, Raphael E. 2013. "Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results." Cancers 5, no. 2: 529-549.