Cancers 2013, 5(2), 529-549; doi:10.3390/cancers5020529
Review

Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results

1 Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 2 Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 3 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA 4 Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
* Author to whom correspondence should be addressed.
Received: 21 March 2013; in revised form: 16 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
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Abstract: Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging.
Keywords: liposarcoma; chemotherapy; molecular-based therapy; clinical trials

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MDPI and ACS Style

Tseng, W.W.; Somaiah, N.; Lazar, A.J.; Lev, D.C.; Pollock, R.E. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers 2013, 5, 529-549.

AMA Style

Tseng WW, Somaiah N, Lazar AJ, Lev DC, Pollock RE. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers. 2013; 5(2):529-549.

Chicago/Turabian Style

Tseng, William W.; Somaiah, Neeta; Lazar, Alexander J.; Lev, Dina C.; Pollock, Raphael E. 2013. "Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results." Cancers 5, no. 2: 529-549.

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