Next Article in Journal
Metabolomic Dynamic Analysis of Hypoxia in MDA-MB-231 and the Comparison with Inferred Metabolites from Transcriptomics Data
Previous Article in Journal
Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma
Cancers 2013, 5(2), 462-490; doi:10.3390/cancers5020462

Regulatory Roles for Long ncRNA and mRNA

Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands
* Author to whom correspondence should be addressed.
Received: 1 March 2013 / Revised: 5 April 2013 / Accepted: 19 April 2013 / Published: 26 April 2013
(This article belongs to the Special Issue Non-coding RNA and Cancer)
View Full-Text   |   Download PDF [1061 KB, 7 May 2013; original version 26 April 2013]   |   Browse Figures


Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs) are frequent events. The current dogma of RNA function describes mRNA to be responsible for the synthesis of proteins, whereas non-coding RNA can have regulatory or epigenetic functions. However, this distinction between protein coding and regulatory ability of transcripts may not be that strict. Here, we review the increasing body of evidence for the existence of multifunctional RNAs that have both protein-coding and trans-regulatory roles. Moreover, we demonstrate that coding transcripts bind to components of the Polycomb Repressor Complex 2 (PRC2) with similar affinities as non-coding transcripts, revealing potential epigenetic regulation by mRNAs. We hypothesize that studies on the regulatory ability of disease-associated mRNAs will form an important new field of research.
Keywords: non-coding RNA; epigenetic; mRNA; polycomb; remodeling; multifunctional; regulatory; transcript; lncRNA; lincRNA non-coding RNA; epigenetic; mRNA; polycomb; remodeling; multifunctional; regulatory; transcript; lncRNA; lincRNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Karapetyan, A.R.; Buiting, C.; Kuiper, R.A.; Coolen, M.W. Regulatory Roles for Long ncRNA and mRNA. Cancers 2013, 5, 462-490.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert