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Cancers 2013, 5(1), 92-130; doi:10.3390/cancers5010092

Mouse Models of Gastric Cancer

Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA
Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA
Author to whom correspondence should be addressed.
Received: 5 December 2012 / Revised: 8 January 2013 / Accepted: 15 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Gastric Cancer)
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Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with Helicobacter species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field.
Keywords: gastric cancer; mouse model; metaplasia; Helicobacter felis; Helicobacter pylori; INS-GAS mice gastric cancer; mouse model; metaplasia; Helicobacter felis; Helicobacter pylori; INS-GAS mice
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hayakawa, Y.; Fox, J.G.; Gonda, T.; Worthley, D.L.; Muthupalani, S.; Wang, T.C. Mouse Models of Gastric Cancer. Cancers 2013, 5, 92-130.

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