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Cancers 2013, 5(1), 92-130; doi:10.3390/cancers5010092
Review
Mouse Models of Gastric Cancer
Yoku Hayakawa 1 , James G. Fox 2 , Tamas Gonda 1 , Daniel L. Worthley 1 , Sureshkumar Muthupalani 2 and Timothy C. Wang 1,*
1
Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA
2
Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA
* Author to whom correspondence should be addressed.
Received: 5 December 2012; in revised form: 8 January 2013 / Accepted: 15 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Gastric Cancer)
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Abstract: Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with Helicobacter species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field.
Keywords: gastric cancer; mouse model; metaplasia; Helicobacter felis; Helicobacter pylori; INS-GAS mice
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MDPI and ACS Style
Hayakawa, Y.; Fox, J.G.; Gonda, T.; Worthley, D.L.; Muthupalani, S.; Wang, T.C. Mouse Models of Gastric Cancer. Cancers 2013, 5, 92-130.
AMA StyleHayakawa Y, Fox JG, Gonda T, Worthley DL, Muthupalani S, Wang TC. Mouse Models of Gastric Cancer. Cancers. 2013; 5(1):92-130.
Chicago/Turabian StyleHayakawa, Yoku; Fox, James G.; Gonda, Tamas; Worthley, Daniel L.; Muthupalani, Sureshkumar; Wang, Timothy C. 2013. "Mouse Models of Gastric Cancer." Cancers 5, no. 1: 92-130.