Next Article in Journal
Hypoxia-Inducible Factors: Mediators of Cancer Progression; Prognostic and Therapeutic Targets in Soft Tissue Sarcomas
Previous Article in Journal
A Novel Three-Colour Fluorescence in Situ Hybridization Approach for the Detection of t(7;12)(q36;p13) in Acute Myeloid Leukaemia Reveals New Cryptic Three Way Translocation t(7;12;16)
Cancers 2013, 5(1), 296-319; doi:10.3390/cancers5010296

Nanomaterials and Autophagy: New Insights in Cancer Treatment

 and *
Received: 1 February 2013 / Revised: 5 March 2013 / Accepted: 19 March 2013 / Published: 21 March 2013
(This article belongs to the Special Issue Autophagy and Cancer)
View Full-Text   |   Download PDF [1166 KB, uploaded 21 March 2013]   |   Browse Figures
Abstract: Autophagy represents a cell’s response to stress. It is an evolutionarily conserved process with diversified roles. Indeed, it controls intracellular homeostasis by degradation and/or recycling intracellular metabolic material, supplies energy, provides nutrients, eliminates cytotoxic materials and damaged proteins and organelles. Moreover, autophagy is involved in several diseases. Recent evidences support a relationship between several classes of nanomaterials and autophagy perturbation, both induction and blockade, in many biological models. In fact, the autophagic mechanism represents a common cellular response to nanomaterials. On the other hand, the dynamic nature of autophagy in cancer biology is an intriguing approach for cancer therapeutics, since during tumour development and therapy, autophagy has been reported to trigger both an early cell survival and a late cell death. The use of nanomaterials in cancer treatment to deliver chemotherapeutic drugs and target tumours is well known. Recently, autophagy modulation mediated by nanomaterials has become an appealing notion in nanomedicine therapeutics, since it can be exploited as adjuvant in chemotherapy or in the development of cancer vaccines or as a potential anti-cancer agent. Herein, we summarize the effects of nanomaterials on autophagic processes in cancer, also considering the therapeutic outcome of synergism between nanomaterials and autophagy to improve existing cancer therapies.
Keywords: nanomaterials; autophagy; cancer; cancer therapy; epigenetic factors nanomaterials; autophagy; cancer; cancer therapy; epigenetic factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Panzarini, E.; Inguscio, V.; Tenuzzo, B.A.; Carata, E.; Dini, L. Nanomaterials and Autophagy: New Insights in Cancer Treatment. Cancers 2013, 5, 296-319.

AMA Style

Panzarini E, Inguscio V, Tenuzzo BA, Carata E, Dini L. Nanomaterials and Autophagy: New Insights in Cancer Treatment. Cancers. 2013; 5(1):296-319.

Chicago/Turabian Style

Panzarini, Elisa; Inguscio, Valentina; Tenuzzo, Bernardetta A.; Carata, Elisabetta; Dini, Luciana. 2013. "Nanomaterials and Autophagy: New Insights in Cancer Treatment." Cancers 5, no. 1: 296-319.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert