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Cancers 2013, 5(1), 255-280; doi:10.3390/cancers5010255
Review

Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review

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Received: 21 December 2012; in revised form: 15 February 2013 / Accepted: 1 March 2013 / Published: 11 March 2013
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Abstract: Vitamin D has reported anti-cancer and anti-inflammatory properties modulated through gene transcription and non-genomic signaling cascades. The purpose of this review was to summarize the available research on interactions and pharmacokinetics between vitamin D and the pharmaceutical drugs used in patients with cancer. Hypercalcemia was the most frequently reported side effect that occurred in high dose calcitriol. The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine; rosuvastatin; prednisone and possibly some chemotherapy drugs. No unusual adverse effects in cancer patients; beyond what is expected from high dose 1,25(OH)2D3 supplementation, were revealed through this review. While sufficient evidence is lacking, supplementation with 1,25(OH)2D3 during chemotherapy appears to have a low risk of interaction. Further interactions with vitamin D3 have not been studied.
Keywords: vitamin D; calcitriol; pharmacokinetics; drug interactions; systematic review vitamin D; calcitriol; pharmacokinetics; drug interactions; systematic review
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kennedy, D.A.; Cooley, K.; Skidmore, B.; Fritz, H.; Campbell, T.; Seely, D. Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review. Cancers 2013, 5, 255-280.

AMA Style

Kennedy DA, Cooley K, Skidmore B, Fritz H, Campbell T, Seely D. Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review. Cancers. 2013; 5(1):255-280.

Chicago/Turabian Style

Kennedy, Deborah A.; Cooley, Kieran; Skidmore, Becky; Fritz, Heidi; Campbell, Tara; Seely, Dugald. 2013. "Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review." Cancers 5, no. 1: 255-280.



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