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Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview
ATreP—Agenzia Provinciale per la Protonterapia, Via F.lli Perini 181, Trento 38122, Italy
* Author to whom correspondence should be addressed.
Received: 7 January 2012; in revised form: 1 March 2012 / Accepted: 5 March 2012 / Published: 7 March 2012
Abstract: Despite the therapeutic advances in neuro-oncology, most patients with glioblastoma ultimately experience local progression/relapse. Re-irradiation has been poorly viewed in the past, mainly due to the overestimated risk of side effects using conventional radiotherapy. To date, thanks to the improvement of several delivery techniques, together with improved imaging capabilities, re-irradiation is a viable salvage treatment option to manage such clinical scenario. A literature overview on the feasibility and efficacy of the different irradiation modalities for recurrent glioblastoma along with considerations on areas of improvement are provided.
Keywords: glioblastoma; recurrence; radiation therapy
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Cite This Article
MDPI and ACS Style
Amelio, D.; Amichetti, M. Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview. Cancers 2012, 4, 257-280.
Amelio D, Amichetti M. Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview. Cancers. 2012; 4(1):257-280.
Amelio, Dante; Amichetti, Maurizio. 2012. "Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview." Cancers 4, no. 1: 257-280.