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• Amichetti, M
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Cancers 2012, 4(1), 257-280; doi:10.3390/cancers4010257

Review

Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview

Dante Amelio*  and Maurizio Amichetti

ATreP—Agenzia Provinciale per la Protonterapia, Via F.lli Perini 181, Trento 38122, Italy

* Author to whom correspondence should be addressed.

Received: 7 January 2012; in revised form: 1 March 2012 / Accepted: 5 March 2012 / Published: 7 March 2012

(This article belongs to the Special Issue Re-Irradiation, Chemotherapy, New Drugs for the (Re)-Treatment of Recurrent Gliomas)

Download PDF Full-Text [234 KB, uploaded 7 March 2012 09:41 CET]

Abstract: Despite the therapeutic advances in neuro-oncology, most patients with glioblastoma ultimately experience local progression/relapse. Re-irradiation has been poorly viewed in the past, mainly due to the overestimated risk of side effects using conventional radiotherapy. To date, thanks to the improvement of several delivery techniques, together with improved imaging capabilities, re-irradiation is a viable salvage treatment option to manage such clinical scenario. A literature overview on the feasibility and efficacy of the different irradiation modalities for recurrent glioblastoma along with considerations on areas of improvement are provided.

Keywords: glioblastoma; recurrence; radiation therapy

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