Next Article in Journal
Epithelial-Mesenchymal Transition Is a Critical Step in Tumorgenesis of Pancreatic Neuroendocrine Tumors
Next Article in Special Issue
External Beam Radiotherapy of Recurrent Glioma: Radiation Tolerance of the Human Brain
Previous Article in Journal / Special Issue
Diagnostic Value of 11C-Methionine (MET) and 18F-Fluorothymidine (FLT) Positron Emission Tomography in Recurrent High-Grade Gliomas; Differentiation from Treatment-Induced Tissue Necrosis
Cancers 2012, 4(1), 257-280; doi:10.3390/cancers4010257

Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview

*  and
ATreP—Agenzia Provinciale per la Protonterapia, Via F.lli Perini 181, Trento 38122, Italy
* Author to whom correspondence should be addressed.
Received: 7 January 2012 / Revised: 1 March 2012 / Accepted: 5 March 2012 / Published: 7 March 2012
View Full-Text   |   Download PDF [234 KB, uploaded 7 March 2012]


Despite the therapeutic advances in neuro-oncology, most patients with glioblastoma ultimately experience local progression/relapse. Re-irradiation has been poorly viewed in the past, mainly due to the overestimated risk of side effects using conventional radiotherapy. To date, thanks to the improvement of several delivery techniques, together with improved imaging capabilities, re-irradiation is a viable salvage treatment option to manage such clinical scenario. A literature overview on the feasibility and efficacy of the different irradiation modalities for recurrent glioblastoma along with considerations on areas of improvement are provided.
Keywords: glioblastoma; recurrence; radiation therapy glioblastoma; recurrence; radiation therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Amelio, D.; Amichetti, M. Radiation Therapy for the Treatment of Recurrent Glioblastoma: An Overview. Cancers 2012, 4, 257-280.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert