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Cancers 2012, 4(1), 184-192; doi:10.3390/cancers4010184

Desmoid Tumors in Pregnant and Postpartum Women

1,* , 2
1 Department of Medicine, University of Colorado Denver, Denver, CO 80045, USA 2 Department of Pharmacy, University of Colorado Denver, Denver, CO 80045, USA 3 Department of the Tumor Registry, University of Colorado Denver, Denver, CO 80045, USA 4 Department of Surgery, University of Colorado Denver, Denver, CO 80045, USA
* Authors to whom correspondence should be addressed.
Received: 4 January 2012 / Revised: 11 February 2012 / Accepted: 13 February 2012 / Published: 21 February 2012
(This article belongs to the Special Issue Desmoid Tumors)
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We report here a review of the current medical literature on pregnancy associated desmoids, including 10 cases of our own. The pertinent findings are that a large percentage of desmoids in females arise in and around pregnancy. Most occur in the abdominal muscles, particularly the right rectus abdominus, perhaps related to trauma from abdominal stretching and fetal movement. While these tumors may regress spontaneously after delivery most can be surgically resected with low recurrence rates even with R1 resections and this is clearly the treatment of choice. Subsequent pregnancies do not appear to result in recurrence in either FAP or non FAP patients. It is not clear from currently available data whether pregnancy associated desmoids are molecularly distinct from other desmoids.
Keywords: desmoid; pregnancy; post-partum; female desmoid; pregnancy; post-partum; female
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Robinson, W.A.; McMillan, C.; Kendall, A.; Pearlman, N. Desmoid Tumors in Pregnant and Postpartum Women. Cancers 2012, 4, 184-192.

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