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Cancers 2011, 3(1), 700-715; doi:10.3390/cancers3010700

Involvement of COUP-TFs in Cancer Progression

Molecular and Cellular Interactions, UMR CNRS 6026, IFR 140 GFSA, University of Rennes 1, Rennes, France
* Author to whom correspondence should be addressed.
Received: 4 January 2011 / Revised: 25 January 2011 / Accepted: 10 February 2011 / Published: 18 February 2011
(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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The orphan receptors COUP-TFI and COUP-TFII are members of the nuclear receptor superfamily that play distinct and critical roles in vertebrate organogenesis, as demonstrated by loss-of-function COUP-TFI and/or COUP-TFII mutant mice. Although COUP-TFs are expressed in a wide range of tissues in adults, little is known about their functions at later stages of development or in organism homeostasis. COUP-TFs are expressed in cancer cell lines of various origins and increasing studies suggest they play roles in cell fate determination and, potentially, in cancer progression. Nevertheless, the exact roles of COUP-TFs in these processes remain unclear and even controversial. In this review, we report both in vitro and in vivo data describing known and suspected actions of COUP-TFs that suggest that these factors are involved in modification of the phenotype of cancer cells, notably of epithelial origin.
Keywords: orphan nuclear receptors; COUP-TFs; cancer progression; steroid hormones; cross-talk orphan nuclear receptors; COUP-TFs; cancer progression; steroid hormones; cross-talk
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Boudot, A.; Le Dily, F.; Pakdel, F. Involvement of COUP-TFs in Cancer Progression. Cancers 2011, 3, 700-715.

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