Next Article in Journal
PCA3 and TMPRSS2-ERG: Promising Biomarkers in Prostate Cancer Diagnosis
Previous Article in Journal
The Prognostic Value of Haplotypes in the Vascular Endothelial Growth Factor A Gene in Colorectal Cancer
Article Menu

Export Article

Open AccessReview
Cancers 2010, 2(3), 1419-1431; doi:10.3390/cancers2031419

The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma

Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Department of Surgery, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Author to whom correspondence should be addressed.
Received: 8 June 2010 / Revised: 28 June 2010 / Accepted: 30 June 2010 / Published: 1 July 2010
View Full-Text   |   Download PDF [136 KB, uploaded 1 July 2010]   |  


Advanced ductal pancreatic carcinoma (PC) remains a challenge for current surgical and medical approaches. It has recently been claimed that radiofrequency ablation (RFA) may be beneficial for patients with locally advanced or metastatic PC. Using the MEDLINE database, we found seven studies involving 106 patients in which PC was treated using RFA. The PC was mainly located in the pancreatic head (66.9%) with a median size of 4.6 cm. RFA was carried out in 85 patients (80.1%) with locally advanced PC and in 21 (19.9%) with metastatic disease. Palliative surgical procedures were carried out in 41.5% of the patients. The average temperature used was 90 °C (with a temperature range of 30–105 °C) and the ratio between the number of passes of the probe and the size of the tumor in centimeters was 0.5 (range of 0.36–1). The median postoperative morbidity and mortality were 28.3% and 7.5%, respectively; the median survival was 6.5 months (range of 1–33 months). In conclusion, RFA is a feasible technique: however, its safety and long-term results are disappointing; Thus, the RFA procedure should not be recommended in clinical practice for a PC patient. View Full-Text
Keywords: pancreatic neoplasms; catheter ablation; surgery pancreatic neoplasms; catheter ablation; surgery

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pezzilli, R.; Ricci, C.; Serra, C.; Casadei, R.; Monari, F.; D’Ambra, M.; Corinaldesi, R.; Minni, F. The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma. Cancers 2010, 2, 1419-1431.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top