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Cancers 2010, 2(2), 842-858; doi:10.3390/cancers2020842
Review

Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?

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Received: 11 March 2010; in revised form: 30 April 2010 / Accepted: 5 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Abstract: Although tumor dormancy is highly prevalent, the underling mechanisms are still mostly unknown. It is unclear which lesions will progress and become a disseminated cancer, and which will remain dormant and asymptomatic. Yet, an improved ability to predict progression would open the possibility of timely treatment and improvement in outcomes. We have recently described the ability of platelets to selectively uptake angiogenesis regulators very early in tumor growth, and proposed their use as an early marker of malignancy. In this review we will summarize current knowledge about these processes and will discuss the possibility of using platelet content to predict presence of occult tumors.
Keywords: tumor dormancy; angiogenesis; platelets; early tumor detection tumor dormancy; angiogenesis; platelets; early tumor detection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Almog, N.; Klement, G.L. Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy? Cancers 2010, 2, 842-858.

AMA Style

Almog N, Klement GL. Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy? Cancers. 2010; 2(2):842-858.

Chicago/Turabian Style

Almog, Nava; Klement, Giannoula Lakka. 2010. "Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?" Cancers 2, no. 2: 842-858.



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