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Cancers 2010, 2(2), 842-858; doi:10.3390/cancers2020842

Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?

Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA
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Received: 11 March 2010 / Revised: 30 April 2010 / Accepted: 5 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Abstract

Although tumor dormancy is highly prevalent, the underling mechanisms are still mostly unknown. It is unclear which lesions will progress and become a disseminated cancer, and which will remain dormant and asymptomatic. Yet, an improved ability to predict progression would open the possibility of timely treatment and improvement in outcomes. We have recently described the ability of platelets to selectively uptake angiogenesis regulators very early in tumor growth, and proposed their use as an early marker of malignancy. In this review we will summarize current knowledge about these processes and will discuss the possibility of using platelet content to predict presence of occult tumors. View Full-Text
Keywords: tumor dormancy; angiogenesis; platelets; early tumor detection tumor dormancy; angiogenesis; platelets; early tumor detection
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Almog, N.; Klement, G.L. Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy? Cancers 2010, 2, 842-858.

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