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Cancers 2010, 2(2), 809-823; doi:10.3390/cancers2020809

An Overview of Biomarkers and Molecular Signatures in HCC

Received: 19 March 2010 / Revised: 30 April 2010 / Accepted: 7 May 2010 / Published: 7 May 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in the patients even with advanced HCC. To identify useful biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression. This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC.
Keywords: hepatocellular carcinoma; biomarker; molecular classification hepatocellular carcinoma; biomarker; molecular classification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yim, S.-H.; Chung, Y.-J. An Overview of Biomarkers and Molecular Signatures in HCC. Cancers 2010, 2, 809-823.

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