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Cancers 2018, 10(8), 251; https://doi.org/10.3390/cancers10080251

The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

1
Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
2
Cell, Molecular and Cancer Biology Graduate Program, Indiana University, Bloomington, IN 47405, USA
3
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 June 2018 / Revised: 20 July 2018 / Accepted: 24 July 2018 / Published: 30 July 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
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Abstract

Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC. View Full-Text
Keywords: inflammation; epithelial ovarian cancer; cytokines; reactive oxygen species; growth factors inflammation; epithelial ovarian cancer; cytokines; reactive oxygen species; growth factors
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Savant, S.S.; Sriramkumar, S.; O’Hagan, H.M. The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer. Cancers 2018, 10, 251.

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