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Cancers 2018, 10(8), 247; https://doi.org/10.3390/cancers10080247

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

1
Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Institute of Cancer and Genomic Medicine, University of Birmingham, Birmingham B15 2TT, UK
3
Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
4
Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 23 July 2018 / Accepted: 25 July 2018 / Published: 27 July 2018
(This article belongs to the Special Issue Epstein–Barr Virus Associated Cancers)
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Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed. View Full-Text
Keywords: TGF-β signalling; Epstein-Barr virus; nasopharyngeal carcinoma; gastric cancer; B-cell lymphoma TGF-β signalling; Epstein-Barr virus; nasopharyngeal carcinoma; gastric cancer; B-cell lymphoma
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Velapasamy, S.; Dawson, C.W.; Young, L.S.; Paterson, I.C.; Yap, L.F. The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers. Cancers 2018, 10, 247.

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