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Cancers 2018, 10(4), 86; https://doi.org/10.3390/cancers10040086

New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma

1
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
2
Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
*
Author to whom correspondence should be addressed.
Received: 3 March 2018 / Revised: 16 March 2018 / Accepted: 20 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Epstein–Barr Virus Associated Cancers)
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Abstract

Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) oncogenic protein that has no intrinsic enzymatic activity or sequence homology to cellular or viral proteins. The oncogenic potential of LMP1 has been ascribed to pleiotropic signaling properties initiated through protein-protein interactions in cytosolic membrane compartments, but the effects of LMP1 extend to nuclear and extracellular processes. Although LMP1 is one of the latent genes required for EBV-immortalization of B cells, the biology of LMP1 in the pathogenesis of the epithelial cancer nasopharyngeal carcinoma (NPC) is more complex. NPC is prevalent in specific regions of the world with high incidence in southeast China. The epidemiology and time interval from seroconversion to NPC onset in adults would suggest the involvement of multiple risk factors that complement the establishment of a latent and persistent EBV infection. The contribution of LMP1 to EBV pathogenesis in polarized epithelia has only recently begun to be elucidated. Furthermore, the LMP1 gene has emerged as one of the most divergent sequences in the EBV genome. This review will discuss the significance of recent advances in NPC research from elucidating LMP1 function in epithelial cells and lessons that could be learned from mining LMP1 sequence diversity. View Full-Text
Keywords: Epstein-Barr virus; LMP1; epithelial infection; nasopharyngeal carcinoma Epstein-Barr virus; LMP1; epithelial infection; nasopharyngeal carcinoma
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Shair, K.H.Y.; Reddy, A.; Cooper, V.S. New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma. Cancers 2018, 10, 86.

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