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Cancers 2009, 1(1), 3-11; doi:10.3390/cancers1010003
Article

BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas

1
, 2
, 3
, 4
, 4
, 5
, 6
, 7
, 6
 and 1,*
1 INSERM U827, Montpellier, France 2 Institut de Génétique Humaine, CNRS UPR 1142, Montpellier, France 3 Equipe de Statistique Appliquée, ESPCI ParisTech, Paris, France 4 CHU Purpan and INSERM U563, Toulouse, France 5 O.O. Bogomoletz National Medical University, Kyiv, Ukraine 6 Department of Functional Genomics, Institute of Molecular Biology and Genetics NASU, Kyiv, Ukraine 7 CRLC, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 27 September 2009 / Revised: 28 October 2009 / Accepted: 13 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Abstract

We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.
Keywords: BAGE; DNA hypomethylation; adenomas; colorectal cancer; biomarker; COBRA BAGE; DNA hypomethylation; adenomas; colorectal cancer; biomarker; COBRA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lana, E.; Brun, M.-E.; Rivals, I.; Selves, J.; Kirzin, S.; Lutsyk, A.P.; Gordiyuk, V.V.; Bibeau, F.; Rynditch, A.; De Sario, A. BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers 2009, 1, 3-11.

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