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BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
INSERM U827, Montpellier, France
Institut de Génétique Humaine, CNRS UPR 1142, Montpellier, France
Equipe de Statistique Appliquée, ESPCI ParisTech, Paris, France
CHU Purpan and INSERM U563, Toulouse, France
O.O. Bogomoletz National Medical University, Kyiv, Ukraine
Department of Functional Genomics, Institute of Molecular Biology and Genetics NASU, Kyiv, Ukraine
CRLC, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 27 September 2009; in revised form: 28 October 2009 / Accepted: 13 November 2009 / Published: 18 November 2009
Abstract: We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.
Keywords: BAGE; DNA hypomethylation; adenomas; colorectal cancer; biomarker; COBRA
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MDPI and ACS Style
Lana, E.; Brun, M.-E.; Rivals, I.; Selves, J.; Kirzin, S.; Lutsyk, A.P.; Gordiyuk, V.V.; Bibeau, F.; Rynditch, A.; De Sario, A. BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers 2009, 1, 3-11.
Lana E, Brun M-E, Rivals I, Selves J, Kirzin S, Lutsyk AP, Gordiyuk VV, Bibeau F, Rynditch A, De Sario A. BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers. 2009; 1(1):3-11.
Lana, Erica; Brun, Marie-Elisabeth; Rivals, Isabelle; Selves, Janick; Kirzin, Sylvain; Lutsyk, Andriy P.; Gordiyuk, Vasily V.; Bibeau, Frédéric; Rynditch, Alla; De Sario, Albertina. 2009. "BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas." Cancers 1, no. 1: 3-11.