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Micromachines 2018, 9(2), 47; doi:10.3390/mi9020047

Design and Performance Assessment of a Solid-State Microcooler for Thermal Neuromodulation

1
CMEMS, University of Minho, 4800-058 Guimarães, Portugal
2
Grenoble Institut des Neurosciences, U1216 Inserm, Université Grenoble Alpes, 38400 Grenoble, France
*
Author to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 25 January 2018 / Accepted: 26 January 2018 / Published: 27 January 2018
(This article belongs to the Special Issue Wireless Microdevices and Systems for Biomedical Applications)
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Abstract

It is well known that neural activity can be modulated using a cooling device. The applications of this technique range from the treatment of medication-resistant cerebral diseases to brain functional mapping. Despite the potential benefits of such technique, its use has been limited due to the lack of suitable thermal modulators. This paper presents the design and validation of a solid-state cooler that was able to modulate the neural activity of rodents without the use of large and unpractical water pipes. A miniaturized thermal control solution based exclusively on solid-state devices was designed, occupying only 5 mm × 5 mm × 3 mm, and featuring the potential for wireless power and communications. The cold side of the device was cooled to 26 °C, while the hot side was kept below 43 °C. This range of temperatures is compatible with brain cooling and efficient enough for achieving some control of neural activity. View Full-Text
Keywords: solid-state cooling; microsystem integration; thermal simulation; thermal neuromodulation; microdevice packaging; biomedical microdevice; neuronal; implantable solid-state cooling; microsystem integration; thermal simulation; thermal neuromodulation; microdevice packaging; biomedical microdevice; neuronal; implantable
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fernandes, J.; Vendramini, E.; Miranda, A.M.; Silva, C.; Dinis, H.; Coizet, V.; David, O.; Mendes, P.M. Design and Performance Assessment of a Solid-State Microcooler for Thermal Neuromodulation. Micromachines 2018, 9, 47.

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