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Micromachines 2018, 9(1), 17; https://doi.org/10.3390/mi9010017

A Wireless Implant for Gastrointestinal Motility Disorders

1
Niche Biomedical, LLC, Los Angeles, CA 90095, USA
2
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
3
Department of Surgery, University of California, Los Angeles, CA 90095, USA
4
Department of Surgery, Stanford University, Stanford, CA 94305, USA
*
Author to whom correspondence should be addressed.
Received: 6 December 2017 / Revised: 21 December 2017 / Accepted: 27 December 2017 / Published: 2 January 2018
(This article belongs to the Special Issue Wireless Microdevices and Systems for Biomedical Applications)
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Abstract

Implantable functional electrical stimulation (IFES) has demonstrated its effectiveness as an alternative treatment option for diseases incurable pharmaceutically (e.g., retinal prosthesis, cochlear implant, spinal cord implant for pain relief). However, the development of IFES for gastrointestinal (GI) tract modulation is still limited due to the poorly understood GI neural network (gut–brain axis) and the fundamental difference among activating/monitoring smooth muscles, skeletal muscles and neurons. This inevitably imposes different design specifications for GI implants. This paper thus addresses the design requirements for an implant to treat GI dysmotility and presents a miniaturized wireless implant capable of modulating and recording GI motility. This implant incorporates a custom-made system-on-a-chip (SoC) and a heterogeneous system-in-a-package (SiP) for device miniaturization and integration. An in vivo experiment using both rodent and porcine models is further conducted to validate the effectiveness of the implant. View Full-Text
Keywords: gastrointestinal stimulation; motility; implant; neuromodulation; bioelectronics medicine; electroceuticals; wireless power and data telemetry gastrointestinal stimulation; motility; implant; neuromodulation; bioelectronics medicine; electroceuticals; wireless power and data telemetry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lo, Y.-K.; Wang, P.-M.; Dubrovsky, G.; Wu, M.-D.; Chan, M.; Dunn, J.C.Y.; Liu, W. A Wireless Implant for Gastrointestinal Motility Disorders. Micromachines 2018, 9, 17.

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