Next Article in Journal
Application of Ultra-Small Micro Grinding and Micro Milling Tools: Possibilities and Limitations
Next Article in Special Issue
Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
Previous Article in Journal
On-Chip Microplasmas for the Detection of Radioactive Cesium Contamination in Seawater
Previous Article in Special Issue
A Rapid Magnetofluidic Micromixer Using Diluted Ferrofluid
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Micromachines 2017, 8(9), 260; doi:10.3390/mi8090260

An Integrated Artificial Cilia Based Microfluidic Device for Micropumping and Micromixing Applications

1
Department of Mechanical Engineering, National Cheng Kung University, Tainan 701, Taiwan
2
Department of Radiology, Taipei City Hospital, Zhongxing branch, Taipei 103, Taiwan
3
Department of Radiology, National Yang-Ming University, Taipei 112, Taiwan
All the authors have contributed equally towards this work.
*
Author to whom correspondence should be addressed.
Received: 25 March 2017 / Revised: 9 August 2017 / Accepted: 17 August 2017 / Published: 24 August 2017
(This article belongs to the Collection Lab-on-a-Chip)
View Full-Text   |   Download PDF [2967 KB, uploaded 24 August 2017]   |  

Abstract

A multi-purpose microfluidic device that can be used for both micromixing and micropropulsion operations has always been in demand, as it would simplify the various process flows associated with the current micro-total analysis systems. In this aspect, we propose a biomimetic artificial cilia-based microfluidic device that can efficiently facilitate both mixing and propulsion sequentially at the micro-scale. A rectangular microfluidic device consists of four straight microchannels that were fabricated using the microfabrication technique. An array of artificial cilia was embedded within one of the channel’s confinement through the aforementioned technique. A series of image processing and micro-particle image velocimetry technologies were employed to elucidate the micromixing and micropropulsion phenomena. Experiment results demonstrate that, with this proposed microfluidic device, a maximum micromixing efficiency and flow rate of 0.84 and 0.089 µL/min, respectively, can be achieved. In addition to its primary application as a targeted drug delivery system, where a drug needs to be homogeneously mixed with its carrier prior to its administration into the target body, this microfluidic device can be used as a micro-total analysis system for the handling of other biological specimens. View Full-Text
Keywords: artificial cilia; micromixing; micropropulsion; micro-particle image velocimetry (µPIV); hydrodynamics artificial cilia; micromixing; micropropulsion; micro-particle image velocimetry (µPIV); hydrodynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, Y.-A.; Panigrahi, B.; Lu, Y.-H.; Chen, C.-Y. An Integrated Artificial Cilia Based Microfluidic Device for Micropumping and Micromixing Applications. Micromachines 2017, 8, 260.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top