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Micromachines 2017, 8(8), 256; doi:10.3390/mi8080256

An Electromagnetically Actuated Double-Sided Cell-Stretching Device for Mechanobiology Research

1
QLD Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane, QLD 4111, Australia
2
School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane, QLD 4111, Australia
3
HealthTech-X, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4111, Australia
4
Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Don Young Road, Nathan, QLD 4111, Australia
5
School of Mechanical Engineering, Sungkyunkwan University, Suwon 16419, Korea
*
Author to whom correspondence should be addressed.
Received: 22 July 2017 / Revised: 4 August 2017 / Accepted: 10 August 2017 / Published: 22 August 2017
(This article belongs to the Special Issue Biomedical Microdevices: Design, Fabrication and Application)
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Abstract

Cellular response to mechanical stimuli is an integral part of cell homeostasis. The interaction of the extracellular matrix with the mechanical stress plays an important role in cytoskeleton organisation and cell alignment. Insights from the response can be utilised to develop cell culture methods that achieve predefined cell patterns, which are critical for tissue remodelling and cell therapy. We report the working principle, design, simulation, and characterisation of a novel electromagnetic cell stretching platform based on the double-sided axial stretching approach. The device is capable of introducing a cyclic and static strain pattern on a cell culture. The platform was tested with fibroblasts. The experimental results are consistent with the previously reported cytoskeleton reorganisation and cell reorientation induced by strain. Our observations suggest that the cell orientation is highly influenced by external mechanical cues. Cells reorganise their cytoskeletons to avoid external strain and to maintain intact extracellular matrix arrangements. View Full-Text
Keywords: biomedical engineering; cell stretching; mechanobiology biomedical engineering; cell stretching; mechanobiology
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Kamble, H.; Vadivelu, R.; Barton, M.; Boriachek, K.; Munaz, A.; Park, S.; Shiddiky, M.J.A.; Nguyen, N.-T. An Electromagnetically Actuated Double-Sided Cell-Stretching Device for Mechanobiology Research. Micromachines 2017, 8, 256.

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